精密医療の時代における動物実験

#tbcss .wpv-pagination-nav-links[data-toolset-views-view-pagination-block="43ce1138731801103cfd3748a3dd45ff"] { text-align: left;justify-content: flex-start; } #tbcss .tb-field[data-toolset-blocks-field="cc518238b14e73a1f77d592867f7a5b0"] { font-size: 11px;text-align: left;color: rgba( 1, 102, 180, 1 ); }  .tb-container .tb-container-inner{width:100%;margin:0 auto} #tbcss .wp-block-toolset-blocks-container.tb-container[data-toolset-blocks-container="3ba5f3115280d883e80356a318880859"] { background: rgba( 243, 243, 243, 1 );padding: 25px; } .tb-grid,.tb-grid>.block-editor-inner-blocks>.block-editor-block-list__layout{display:grid;grid-row-gap:25px;grid-column-gap:25px}.tb-grid-item{background:#d38a03;padding:30px}.tb-grid-column{flex-wrap:wrap}.tb-grid-column>*{width:100%}.tb-grid-column.tb-grid-align-top{width:100%;display:flex;align-content:flex-start}.tb-grid-column.tb-grid-align-center{width:100%;display:flex;align-content:center}.tb-grid-column.tb-grid-align-bottom{width:100%;display:flex;align-content:flex-end} #tbcss .wpv-view-output[data-toolset-views-view-editor="9ecf0ad8639c4d2eb14c607e7d90acbb"] > .tb-grid-column:nth-of-type(3n + 1) { grid-column: 1 } #tbcss .wpv-view-output[data-toolset-views-view-editor="9ecf0ad8639c4d2eb14c607e7d90acbb"] > .tb-grid-column:nth-of-type(3n + 2) { grid-column: 2 } #tbcss .wpv-view-output[data-toolset-views-view-editor="9ecf0ad8639c4d2eb14c607e7d90acbb"] > .tb-grid-column:nth-of-type(3n + 3) { grid-column: 3 } #tbcss .wpv-view-output[data-toolset-views-view-editor="9ecf0ad8639c4d2eb14c607e7d90acbb"] .js-wpv-loop-wrapper > .tb-grid { grid-template-columns: minmax(0, 0.3333fr) minmax(0, 0.3333fr) minmax(0, 0.3333fr);grid-auto-flow: row } #tbcss .tb-field[data-toolset-blocks-field="dc2c6421f105727557deb0125a823e19"] { font-size: 16px;text-align: left;color: rgba( 1, 102, 180, 1 ); }  #tbcss h5.tb-heading[data-toolset-blocks-heading="01751bc11cd861416022fd857afaa68d"]  { font-size: 14px;text-align: left; }  #tbcss h5.tb-heading[data-toolset-blocks-heading="01751bc11cd861416022fd857afaa68d"] a  { color: rgba( 1, 102, 180, 1 );font-size: 20px; } #tbcss h5.tb-heading[data-toolset-blocks-heading="01751bc11cd861416022fd857afaa68d"] a:hover  { color: rgba( 91, 210, 216, 1 );font-weight: bold; } #tbcss h5.tb-heading[data-toolset-blocks-heading="01751bc11cd861416022fd857afaa68d"] a:active  { color: rgba( 255, 87, 0, 1 ); } .tb-grid,.tb-grid>.block-editor-inner-blocks>.block-editor-block-list__layout{display:grid;grid-row-gap:25px;grid-column-gap:25px}.tb-grid-item{background:#d38a03;padding:30px}.tb-grid-column{flex-wrap:wrap}.tb-grid-column>*{width:100%}.tb-grid-column.tb-grid-align-top{width:100%;display:flex;align-content:flex-start}.tb-grid-column.tb-grid-align-center{width:100%;display:flex;align-content:center}.tb-grid-column.tb-grid-align-bottom{width:100%;display:flex;align-content:flex-end} #tbcss .wp-block-toolset-blocks-grid.tb-grid[data-toolset-blocks-grid="f3b473ff6ddbba1d1168eb6e735d2314"] { padding-bottom: 30px;grid-template-columns: minmax(0, 0.5fr) minmax(0, 0.5fr);grid-auto-flow: row } #tbcss .wp-block-toolset-blocks-grid.tb-grid[data-toolset-blocks-grid="f3b473ff6ddbba1d1168eb6e735d2314"] > .tb-grid-column:nth-of-type(2n + 1) { grid-column: 1 } #tbcss .wp-block-toolset-blocks-grid.tb-grid[data-toolset-blocks-grid="f3b473ff6ddbba1d1168eb6e735d2314"] > .tb-grid-column:nth-of-type(2n + 2) { grid-column: 2 } #tbcss .wpv-custom-search-filter-submit[data-toolset-views-custom-search-submit="a3b8d1c4c4e77dad388dd05dadcab741"] { text-align: left;text-align: center; } #tbcss .wpv-custom-search-filter-submit[data-toolset-views-custom-search-submit="a3b8d1c4c4e77dad388dd05dadcab741"] .wpv-submit-trigger { background-color: rgba( 1, 102, 180, 1 );padding: 20px 30px 20px 30px;border: 0px solid rgba( 0, 0, 0, 1 );border-radius: 4px;text-align: center; } #tbcss .wp-block-toolset-blocks-grid-column.tb-grid-column[data-toolset-blocks-grid-column="3034fbe886c11054e95b46b09d3e4112"] { display: flex; } #tbcss .wpv-custom-search-filter[data-toolset-views-custom-search-filter="fa5236e2fdaaa5caca8b85a50e260df3"] label, #tbcss .wpv-custom-search-filter[data-toolset-views-custom-search-filter="fa5236e2fdaaa5caca8b85a50e260df3"] .editor-rich-text__editable { font-size: 16px;color: rgba( 1, 102, 180, 1 ); } #tbcss .wpv-custom-search-filter[data-toolset-views-custom-search-filter="418a28d80d3cab284a6ac605d4e3bb0e"] label, #tbcss .wpv-custom-search-filter[data-toolset-views-custom-search-filter="418a28d80d3cab284a6ac605d4e3bb0e"] .editor-rich-text__editable { font-size: 16px;color: rgba( 1, 102, 180, 1 ); } #tbcss .wp-block-toolset-blocks-grid-column.tb-grid-column[data-toolset-blocks-grid-column="1bec8e2caa4d6da8a3027f92ce0fd30a"] { display: flex; } #tbcss .wp-block-toolset-blocks-grid-column.tb-grid-column[data-toolset-blocks-grid-column="1bec8e2caa4d6da8a3027f92ce0fd30a"] p { font-family: Allan;font-weight: regular; } #tbcss .wpv-custom-search-filter[data-toolset-views-custom-search-filter="f4215e6ab06bcb05659a9395eb3d62da"] label, #tbcss .wpv-custom-search-filter[data-toolset-views-custom-search-filter="f4215e6ab06bcb05659a9395eb3d62da"] .editor-rich-text__editable { font-size: 16px;color: rgba( 1, 102, 180, 1 ); } #tbcss h4.tb-heading[data-toolset-blocks-heading="083d6c11bd8364f302177e770c60f00f"]  { color: rgba( 1, 102, 180, 1 );text-align: left;border-radius: 0;padding: 5px 10px 5px 10px;margin-bottom: 15px;border-left: 8px solid rgba( 1, 102, 180, 1 ); }  .tb-container .tb-container-inner{width:100%;margin:0 auto} #tbcss .wp-block-toolset-blocks-container.tb-container[data-toolset-blocks-container="593d18caef4fed3086a739558e3898a5"] { background: rgba( 219, 212, 212, 1 );padding: 25px; } @media only screen and (max-width: 750px) {  .tb-container .tb-container-inner{width:100%;margin:0 auto}.tb-grid,.tb-grid>.block-editor-inner-blocks>.block-editor-block-list__layout{display:grid;grid-row-gap:25px;grid-column-gap:25px}.tb-grid-item{background:#d38a03;padding:30px}.tb-grid-column{flex-wrap:wrap}.tb-grid-column>*{width:100%}.tb-grid-column.tb-grid-align-top{width:100%;display:flex;align-content:flex-start}.tb-grid-column.tb-grid-align-center{width:100%;display:flex;align-content:center}.tb-grid-column.tb-grid-align-bottom{width:100%;display:flex;align-content:flex-end} #tbcss .wpv-view-output[data-toolset-views-view-editor="9ecf0ad8639c4d2eb14c607e7d90acbb"] > .tb-grid-column:nth-of-type(3n + 1) { grid-column: 1 } #tbcss .wpv-view-output[data-toolset-views-view-editor="9ecf0ad8639c4d2eb14c607e7d90acbb"] > .tb-grid-column:nth-of-type(3n + 2) { grid-column: 2 } #tbcss .wpv-view-output[data-toolset-views-view-editor="9ecf0ad8639c4d2eb14c607e7d90acbb"] > .tb-grid-column:nth-of-type(3n + 3) { grid-column: 3 } #tbcss .wpv-view-output[data-toolset-views-view-editor="9ecf0ad8639c4d2eb14c607e7d90acbb"] .js-wpv-loop-wrapper > .tb-grid { grid-template-columns: minmax(0, 0.3333fr) minmax(0, 0.3333fr) minmax(0, 0.3333fr);grid-auto-flow: row }   .tb-grid,.tb-grid>.block-editor-inner-blocks>.block-editor-block-list__layout{display:grid;grid-row-gap:25px;grid-column-gap:25px}.tb-grid-item{background:#d38a03;padding:30px}.tb-grid-column{flex-wrap:wrap}.tb-grid-column>*{width:100%}.tb-grid-column.tb-grid-align-top{width:100%;display:flex;align-content:flex-start}.tb-grid-column.tb-grid-align-center{width:100%;display:flex;align-content:center}.tb-grid-column.tb-grid-align-bottom{width:100%;display:flex;align-content:flex-end} #tbcss .wp-block-toolset-blocks-grid.tb-grid[data-toolset-blocks-grid="f3b473ff6ddbba1d1168eb6e735d2314"] { grid-template-columns: minmax(0, 0.5fr) minmax(0, 0.5fr);grid-auto-flow: row } #tbcss .wp-block-toolset-blocks-grid.tb-grid[data-toolset-blocks-grid="f3b473ff6ddbba1d1168eb6e735d2314"] > .tb-grid-column:nth-of-type(2n + 1) { grid-column: 1 } #tbcss .wp-block-toolset-blocks-grid.tb-grid[data-toolset-blocks-grid="f3b473ff6ddbba1d1168eb6e735d2314"] > .tb-grid-column:nth-of-type(2n + 2) { grid-column: 2 } #tbcss .wp-block-toolset-blocks-grid-column.tb-grid-column[data-toolset-blocks-grid-column="3034fbe886c11054e95b46b09d3e4112"] { display: flex; } #tbcss .wp-block-toolset-blocks-grid-column.tb-grid-column[data-toolset-blocks-grid-column="1bec8e2caa4d6da8a3027f92ce0fd30a"] { display: flex; }  .tb-container .tb-container-inner{width:100%;margin:0 auto} } @media only screen and (max-width: 599px) {  .tb-container .tb-container-inner{width:100%;margin:0 auto}.tb-grid,.tb-grid>.block-editor-inner-blocks>.block-editor-block-list__layout{display:grid;grid-row-gap:25px;grid-column-gap:25px}.tb-grid-item{background:#d38a03;padding:30px}.tb-grid-column{flex-wrap:wrap}.tb-grid-column>*{width:100%}.tb-grid-column.tb-grid-align-top{width:100%;display:flex;align-content:flex-start}.tb-grid-column.tb-grid-align-center{width:100%;display:flex;align-content:center}.tb-grid-column.tb-grid-align-bottom{width:100%;display:flex;align-content:flex-end} #tbcss .wpv-view-output[data-toolset-views-view-editor="9ecf0ad8639c4d2eb14c607e7d90acbb"]  > .tb-grid-column:nth-of-type(1n+1) { grid-column: 1 } #tbcss .wpv-view-output[data-toolset-views-view-editor="9ecf0ad8639c4d2eb14c607e7d90acbb"] .js-wpv-loop-wrapper > .tb-grid { grid-template-columns: minmax(0, 1fr);grid-auto-flow: row }   .tb-grid,.tb-grid>.block-editor-inner-blocks>.block-editor-block-list__layout{display:grid;grid-row-gap:25px;grid-column-gap:25px}.tb-grid-item{background:#d38a03;padding:30px}.tb-grid-column{flex-wrap:wrap}.tb-grid-column>*{width:100%}.tb-grid-column.tb-grid-align-top{width:100%;display:flex;align-content:flex-start}.tb-grid-column.tb-grid-align-center{width:100%;display:flex;align-content:center}.tb-grid-column.tb-grid-align-bottom{width:100%;display:flex;align-content:flex-end} #tbcss .wp-block-toolset-blocks-grid.tb-grid[data-toolset-blocks-grid="f3b473ff6ddbba1d1168eb6e735d2314"] { grid-template-columns: minmax(0, 1fr);grid-auto-flow: row } #tbcss .wp-block-toolset-blocks-grid.tb-grid[data-toolset-blocks-grid="f3b473ff6ddbba1d1168eb6e735d2314"]  > .tb-grid-column:nth-of-type(1n+1) { grid-column: 1 } #tbcss .wp-block-toolset-blocks-grid-column.tb-grid-column[data-toolset-blocks-grid-column="3034fbe886c11054e95b46b09d3e4112"] { display: flex; } #tbcss .wp-block-toolset-blocks-grid-column.tb-grid-column[data-toolset-blocks-grid-column="1bec8e2caa4d6da8a3027f92ce0fd30a"] { display: flex; }  .tb-container .tb-container-inner{width:100%;margin:0 auto} } 

論文概要

前臨床研究における動物実験は、新しい薬物治療がヒトを対象とした臨床試験に進む前段階で、有効性や毒性、安全性を評価する基盤として長年にわたり重要な役割を果たしてきた。しかし、人体生理の複雑な性質や癌などの疾患における複雑性を考慮し、本稿では認識論と倫理学の観点から、トランスレーショナルリサーチにおける動物実験の役割を批判的に検証する。

動物を保護することの倫理的義務は、人間の利益のために利用する手段としての価値を超えるものであり、動物たちのウェルビーイングに内在する価値を根拠としている。したがって、ここでは医学研究におけるパラダイムシフト、すなわち、新しい代替手法 New Approach Methodologies (NAMs) が単なる補助ツールではなく、医学研究で動物を使うことへの完全な代替手段であることを提唱する。この文脈において動物実験の代替は必須の原則であり、他のあらゆる事情より優先されるべき責務である。

原文タイトル："Lost in translation?" Animal research in the era of precision medicine

論文著者：Hamideh Frühwein, Norbert W Paul

公開日： 2025/02/04

論文URL：https://doi.org/10.1186/s12967-025-06084-3

動物の未来-FACTSへ戻る